Genetics Cancer

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  Emergency

  If any of the following are present or suspected, please refer the patient to the emergency department (via ambulance if necessary) or follow local emergency care protocols or seek emergent medical advice if in a remote region.

  • No referrals to emergency relating to clinical genetics
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  CPC in scope Not an exhaustive list

  Please note this is not an exhaustive list of all conditions for outpatient services and does not exclude consideration for referral unless specifically stipulated in the CPC out of scope section.

  • Breast cancer genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Colorectal or small bowel cancer genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Dermatological cancer or tumour (AFF): Individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Endocrine cancer or tumour genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Family history: Individual with a family history of cancer from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Female gynaecological cancer or tumour genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Gastric cancer genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Gastrointestinal polyps (not cancer) genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Haematological malignancy genetics - Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Individual who has undergone mainstreamed, research or private genetic testing for cancer predisposition genes ADULT PAEDIATRIC
  • Musculoskeletal or soft tissue tumour or cancer: relating to cancer genetics ADULT PAEDIATRIC
  • Neurological or ocular tumour or cancer: Individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Paediatric or adolescent and young adult (AYA) cancer genetics- Affected individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified PAEDIATRIC
  • Pancreatic or biliary tract tumour or cancer: Individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Respiratory or oropharyngeal tumour or cancer: Individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
  • Untested blood relative of a person with an identified mutation in a cancer predisposition gene ADULT PAEDIATRIC
  • Urological tumour or cancer: Individual from a family in whom a mutation in a cancer predisposition gene has NOT been identified ADULT PAEDIATRIC
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  CPC out of scope

  The following are not routinely provided in a public Genetics Cancer service.

  Cancer Genetics

  • Individuals with a personal history of colorectal cancer diagnosed at age ≥ 40 years with loss of MLH1 and PMS2 on mismatch repair immunohistochemistry AND presence of the BRAF V600E mutation in tumour AND have no other personal or family history suggestive of a familial predisposition to colorectal cancer or gastrointestinal polyps.  For further information please see Colorectal Cancer condition within Genetics CPC and MMR IHC document on the GHQ website.
  • Individuals with a personal history of colorectal cancer diagnosed at age ≥ 40 years with normal mismatch repair immunohistochemistry AND have no other personal or family history suggestive of a familial predisposition to colorectal cancer or gastrointestinal polyps.  For further information please see Colorectal Cancer condition within Genetics CPC and MMR IHC document on the GHQ website.
  • Individuals with a personal history of endometrial cancer diagnosed at age ≥ 50 years with loss of MLH1 and PMS2 on mismatch repair immunohistochemistry AND presence of MLH1 promoter methylation in tumour AND have no other personal or family history suggestive of a familial predisposition to endometrial cancer.  For further information please see Female gynaecological cancer or tumour condition within Genetics CPC and MMR IHC document on the GHQ website.
  • Individuals with a personal history of endometrial cancer diagnosed at age ≥ 50 years with normal mismatch repair immunohistochemistry AND have no other personal or family history suggestive of a familial predisposition to endometrial cancer.  For further information please see Female gynaecological cancer or tumour condition within Genetics CPC and MMR IHC document on the GHQ website.
  • Individuals with melanoma who do NOT fulfil the following criteria:
    • 2 or more affected first or second degree relatives AND a 4 factor GenoMEL probability of a CDKN2A mutation of ≥20%
    • BAP1 deficiency on immunohistochemistry
  • Individuals who are solely being referred due to a family history of melanoma
  • Individuals who are solely being referred due to a family history of pancreatic cancer who do NOT fulfil one of the following criteria:
    • Three or more relatives with pancreatic cancer, at least one of whom is a first degree relative.
    • At least two first degree relatives with pancreatic cancer
  • Individuals with a family history of cancer who are solely being referred for further assessment and management of a suspected new cancer (e.g. elevated tumour markers, abnormal breast imaging).
  • Individuals at increased risk of cancer who are solely being referred for ongoing management of cancer risk such as surveillance or risk reducing surgery.
  • Individuals solely being referred due to a personal and/or family history of cancer which is unlikely to be associated with a familial cancer predisposition syndrome or increased risk of cancer for unaffected family members.
  • Individuals solely being referred due to a family history of prostate cancer.
  • Individuals who are not residents of Queensland.
  • Individuals solely referred for a family history of bowel cancer who do NOT fulfil one or more of the following criteria:
    • At high lifetime risk of bowel cancer according to NHMRC guidelines
  • Individuals solely referred for a family history of breast cancer who do NOT fulfil one or more of the following criteria:
    • fits in the high (substantially increased) lifetime risk category according to iPrevent, Tyrer-Cuzick or CanRisk
    • Two 1 degree or 2 degree relatives on one side of the family diagnosed with breast or ovarian cancer plus one or more of the following features on the same side of the family:
      • breast cancer diagnosed before the age of 40, bilateral breast cancer, breast and ovarian cancer in the same women, Jewish ancestry, breast cancer in a male relative